This book provides an up to date review of the fundamentals of sphingolipid metabolism and its role in metabolic diseases Focusing on the sphingolipid de novo synthesis pathway the effect of sphingomyelin ceramide and sphingosine 1 phosphate and linkage between sphingolipids and other lipids such as cholesterol it covers serine palmitoyltransferase ceramide synthases ceramidases sphingosine kinases and sphingomyelin synthases and more While highlighting how rare diseases related to abnormal glycosphingolipid metabolism this publication introduces sphingolipid metabolism related diseases such as lung diseases and cancers as well as sphingolipid circadian regulation The book demonstrates advances and limitations of research on sphingolipid metabolism and its roles in metabolic diseases and other diseases It offers graduate students and researchers a coherent overview of sphingolipids as well as the limitations of current research in the field and promotes further studies on metabolic diseases as well as pharmaceutical research on drug discovery based on sphingolipid de novo synthase
